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Index > Protein center > OLIG2(Gene name) > Human
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  • OLIG2 (Gene name),
  • Oligodendrocyte transcription factor 2 (Protein name ),  OLIG2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    OLIG2(BHLHB1;BHLHE19;PRKCBP2;RACK17);
    Protein name:
    Oligodendrocyte transcription factor 2(Oligo2);
    Alternative:
    Class E basic helix-loop-helix protein 19(bHLHe19);Class B basic helix-loop-helix protein 1(bHLHb1);Protein kinase C-binding protein RACK17;Protein kinase C-binding protein 2;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with NKX2-2.
    Function:
    Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development.
    Subcellular Location:
    Nucleus Cytoplasm The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2.
    Protein Attributes:
    Sequence length:
    323
    Sequence:
    50:
    MDSDASLVSS | RPSSPEPDDL | FLPARSKGSS | GSAFTGGTVS | SSTPSDCPPE | 
    100:
    LSAELRGAMG | SAGAHPGDKL | GGSGFKSSSS | STSSSTSSAA | ASSTKKDKKQ | 
    150:
    MTEPELQQLR | LKINSRERKR | MHDLNIAMDG | LREVMPYAHG | PSVRKLSKIA | 
    200:
    TLLLARNYIL | MLTNSLEEMK | RLVSEIYGGH | HAGFHPSACG | GLAHSAPLPA | 
    250:
    ATAHPAAAAH | AAHHPAVHHP | ILPPAAAAAA | AAAAAAAVSS | ASLPGSGLPS | 
    300:
    VGSIRPPHGL | LKSPSAAAAA | PLGGGGGGSG | ASGGFQHWGG | MPCPCSMCQV | 
    323:
    PPPHHHVSAM | GAGSLPRLTS | DAK
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    MIM:
    UniGene:
    String:
    SMR:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Oligo2
    Cat.:
    E15290h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Oligo2
    Cat.:
    E15290c
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Oligo2
    Cat.:
    E15290m
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Oligo2
    Cat.:
    U15290c
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Oligo2
    Cat.:
    U15290m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Oligo2
    Cat.:
    U15290h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Oligo2
    Cat.:
    P15290Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Oligo2
    Polyclonal Antibody for Human Oligo2
    Cat.:
    P15290Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Oligo2
    Monoclonal Antibody for Human Oligo2
    Monoclonal Antibody for Human Oligo2
    Protein for Human Oligo2
    Protein for Human Oligo2
    Protein for Human Oligo2

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    References
    1. 1.
      "Protein kinase C-binding protein."
      Kuroda S. , Tokunaga C. , Kiyohara Y. , Konishi H. , Kikkawa U.
      Submitted (1996-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Hippocampus.
    2. 2.
      "The t(14;21)(q11.2;q22) chromosomal translocation associated with T-cell acute lymphoblastic leukemia activates the BHLHB1 gene."
      Wang J. , Jani-Sait S.N. , Escalon E.A. , Carroll A.J. , de Jong P.J. , Kirsch I.R. , Aplan P.D.
      Proc. Natl. Acad. Sci. U.S.A.97:3497-3502(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    5. 5.
      "OLIG2 as a specific marker of oligodendroglial tumour cells."
      Marie Y. , Sanson M. , Mokhtari K. , Leuraud P. , Kujas M. , Delattre J.-Y. , Poirier J. , Zalc B. , Hoang-Xuan K.
      Lancet358:298-300(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    6. 6.
      "Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors."
      Lu Q.R. , Park J.K. , Noll E. , Chan J.A. , Alberta J.A. , Yuk D.-I. , Alzamora M.G. , Louis D.N. , Stiles C.D. , Rowitch D.H. , Black P.M.
      Proc. Natl. Acad. Sci. U.S.A.98:10851-10856(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
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